Dax1 Binds to Oct3/4 and Inhibits Its Transcriptional Activity in Embryonic Stem Cells
نویسندگان
چکیده
منابع مشابه
Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells.
Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of blastocysts. Transcription factor Oct3/4 is an indispensable factor in the self-renewal of ES cells. In this study, we searched for a protein that would interact with Oct3/4 in ES cells and identified an orphan nuclear hormone receptor, Dax1. The association of Dax1 with Oct3/4 was mediated through the POU-speci...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2009
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.01863-08